Among such remarkable achievements, the development of Ethiopia’s eHealth architecture (eHA) is a breakthrough to coordinate and streamline the various fragmented eHealth initiatives. The architecture is the foundational plan or blueprint that creates a framework for how the HIS subsystems interact. It delineates the different components of the HIS continuum, as shown in Figure 1, and identifies the key systems and functionalities that are needed to support the mission and goals of the MOH. The eHA also depicts a conceptual framework for how the different eHealth system components interact, and defines how interaction among these systems can be made possible through interoperability services.